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이은남
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Abstract
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This study was carried out to identify the important risk factors for reduced bone mass of postmenopausal RA patients and to develop discriminant function which can classify postmenopausal RA patients with either reduced or normal bone mass.
Through the literature review, individual characteristics such as age, body weight, height. age of menarche, duration of menopause, gravity, parity, and breast feeding period and factors of life style such as milk consumption exercise habit. alcohol intake, cigarette smoking, coffee consumption, disease activity, corticosteroid therapy were identified as influencing factors of reduced bone mass in RA patients
Sixty eight postmenopausal women with rheumatoid arthritis aged between 42 and 76 were selected among those who checked bone mineral density in lumbar spine and femur from October. 1998 to April. 1999 at Dong-a university hospital in Pusan.
Assessment of disease activity, duration of disease and corticosteroid therapy were made by the same rheumatologist and included Ritchie articular index, erythrocyte sedimentation rate, and C-reactive measuring bone protein on mineral density. Cumulative steroid dosage was calculated from the daily dosage multiplied by the number of days received. The information of other risk factor including health assessment score, individual characteristics and life style factors were collected by questionnaire. Bone mineral density(BMD) was measured using DXA at lumbar spine and femoral Ward´s triangle. Discriminant function (regression equation) was developed for estimating the likelihood of the presence or absence of reduced bone mass. The results are as follows:
Among the subjects, thirteen(l9.1%) exhibited osteoporosis in lumbar spine and twenty four(35.3%) exhibited osteoporosis in femoral Ward´s triangle.
For lumbar spine, the variables significant were age, body weight, health assessment score, while for femoral Ward´s triangle, age, body weight, duration of disease. But disease activity and corticosteroid therapy were not signigicant to distinguish reduced bone mass from normal bone mass.
When the discriminant function was evaluated by comparing the observed outcome with predicted outcome, the discriminant function correctly classified 85.4% of patients with reduce bone mass and 63.0% of patients with normal bone mass in the lumbar spine and 100% of patients with reduced bone mass and 9.1% of patients with normal bone mass in the femoral Ward´s triangle.
In summary, we found that osteoporosis in postmenopausal women with RA is more evident at the femur than the lumbar spine. Also the important discriminant factors of reduced bone mass postmenopausal women with RA were age, body weight, duration of disease and health disability.
In nursing situation, the efforts to improve of functional capacity of postmenopausal women with rheumatoid arthritis should be considered to prevent osteoporosis and fractures.
Also we recommend those postmenopausal women with RA who are classified as a group of the reduced bone mass in the discriminant function should examine the bone mineral density to further examine the usefulness of this discriminant function.
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KeyWords
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원문 및 링크아웃 정보
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등재저널 정보
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